

Don’t forget to install risers.
Where are you going to mount the power and reset buttons and front panel lights?
If you’re using wifi built into the motherboard, your connection is going to suffer. Consider a hard line or external USB dongle.
It will be very difficult to make a “tasteful” number of holes that also give adequate cooling.

Cool. Sounds like you’ve got most of the hard stuff figured out. I like the vent idea.
While you’re at it, it would be really convenient if you could pull the whole drawer out and get access to the PC parts. Maybe wire in a harness so you can quickly dis/connect everything?